The mathematical formulation of quantum mechanics by Werner Heisenberg and Erwin Schrödinger was originally in terms of unbounded self-adjoint operators on a Hilbert space. The fundamental operators corresponding to position and momentum satisfy the Heisenberg commutation relations. Quadratic polynomials in these operators, which include the harmonic oscillator, are also closed under taking commutators.
A large amount of operator theory was developed in the 1920s and 1930s to provide a rigorous foundation for quantum mechanics. Part of the theory was formulated in terms of unitary groups of operators, largely through the contributions of Hermann Weyl, Marshall Stone and John von Neumann. In turn these results in mathematical physics were subsumed within mathematical analysis, starting with the 1933 lecture notes of Norbert Wiener, who used the heat kernel for the harmonic oscillator to derive the properties of the Fourier transform.
https://en.wikipedia.org/wiki/Oscillator_representation
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